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1) What is the most important intracellular microbicidal killing method:
Oxygen dependent microbe killing
2) Phagocytosis initiates activity of the HEXOSE MONOPHOSPHATE shunt, causing an oxidative burst, which supplies electrons to NADPH oxidase in the phagosomal membrane.
3)One of the products of the oxidase is SUPEROXIDE ION, which is further converted to _HYDROGREN PEROXIDE__ by dismutation, which is further mutated to_HYDROXYL RADICAL.
4)What does the hyd. Peroxide do for us?
In the presence of myeloperoxidase and a halide ion, it oxidizes microbial proteins and disrupts cell walls.
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thanks
i was a bit apprehensive bcos goljan says mult mye!!!!!
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1)Describe chronic granulomatous disease of childhood:
Usually X-linked
Characterized by deficient activity of NADPH oxidase
Phagocytic cells ingest but do not kill certain micro-organisms
2)Which organisms are ingested but NOT destroyed:
Catalase positive “ these guys can destroy the hyd. Peroxide generated by bacterial metabolism, and the PMNs are deficient so they cannot generate additional hyd.peroxide, thus none is available as a substrate for myeloperoxidase system
3)Examples of CAT(+) and CAT(-) organisms:
S.aureus “ CAT(+)
Strep “ CAT(-)
4)What type of inheritance is Chediak-Higashi:
Autosomal recessive
Marked by the presence of abnormal WBCs
The WBCs have impaired Chemotaxis and migration (microtubules)
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HEY FOLKS I will post some easy pharmaco MCQs, please answer STAT so you can check how your hypocampus is working on it what do u think?
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thnx for ur qs okt3
i am going back to musculoskeletal,i ahv to finish it +cns tonight inshallah!
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Salaam, whats up team? Good to see every1 working hard.. just thought id drop one to see how every1 doing
What toxin does Aeromonas hydrophila produce that causes gastroenteritis, and by what mechanism does it do so?
Cheers!
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lol armani what a q
wel it is bacteria ,causing cholera or emoebic dysentry like gastro
and toxin is aerolysin.mainly after sea food.
did u get this in exam?lol
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lol unfortunately yes genious, they asked me what mechansim.. i took a guess and picked: Secretery. The only other choice i remember was "osmosis".
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salaam armani,
Hmmmmm, is it the way u stop by and say Salaam?
Aeromonas hydrophila produces Aerolysin Cytotoxic Enterotoxin , a toxin that can cause tissue damage. It is believed that this bacterium aids in the infection of diseases, but do not cause the diseases themselves.
disease similar to cholera.
Infos from Wiki,no clue
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