spherocytosis - kabiraj

[ArchivalUser]

In hereditary spherocytosis, which one is most unlikely:

A. Increased mean corpuscular Hb concentration
B. Increased sodium permeability of the spherocytes
C. Jaundice due to increased unconjugated bilirubin
D. Mutation in spectrin protein is the most common defect
E. Increased incidence of calcium bilirubinate gallstones due to increased conc of conjugated bilirubin in bile

[ArchivalUser]

B?

[ArchivalUser]

e.stones are due to the increased incidence of unconjugated bilirubin

[ArchivalUser]

nope....

[ArchivalUser]

is it d?

[ArchivalUser]

EE

[ArchivalUser]

c prob ?

[ArchivalUser]

bravo biochem! u got it! it's not spectrin... it's rather ANKYRIN, mutation in which lies the most common defect of HS. Incidence of defect in spectrin occurs less than that of ankyrin, according to Goljan.

[ArchivalUser]

I had no patience to wait so I read about it in uptodate
I will however keep my discovery to myself and give others a chance to try

[ArchivalUser]

aa,in spherocytosis actually there will be decrease in cell vol,so mchc might be decreased.