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MOA of glyburide..
Sulfonylureas such as glyburide likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin
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Mechanism of action of rifampicin
Rifampicin inhibits DNA-dependent RNA polymerase in bacterial cells by binding its beta-subunit, thus preventing transcription of messenger RNA (mRNA) and subsequent translation to proteins. Its lipophilic nature makes it a good candidate to treat the meningitis form of tuberculosis, which requires distribution to the central nervous system and penetration through the blood-brain barrier.
Indications
Rifampicin is typically used to treat Mycobacterium infections, including tuberculosis and leprosy; and also has a role in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in combination with fusidic acid. It is used in prophylactic therapy against Neisseria meningitidis (meningococcal) infection.
It is also used to treat infection by Listeria species, Neisseria gonorrhoeae, Haemophilus influenzae and Legionella pneumophila. For these non-standard indications, sensitivity testing should be done (if possible) before starting rifampicin therapy. Rifampicin resistance develops quickly during treatment and rifampicin monotherapy should not be used to treat these infections ” it should be used in combination with other antibiotics. With multidrug therapy (MDT) used as the standard treatment of leprosy, rifampicin is always used in combination with dapsone and clofazimine.
Enterobacteriaceae, Acinetobacter and Pseudomonas species are intrinsically resistant to rifampicin.
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Treatment of absence seizures...
Absence seizures appear to respond well to valproic acid (trade name: Depakote), ethosuximide (trade name: Zarontin), and lamotrigine (Lamictal).
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what happens with heparin treatment sometimes like dermal vascular thrombosis and skin necrosis is due to the transient protien C deficiency due to the short half life of protien C and factor 8so the extrinsic factor andprot.C r inactivated while the intrinsic pathways r active
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Coxsackie A disease
The most well known Coxsackie A disease is hand, foot and mouth disease (unrelated to foot and mouth disease), a common childhood illness, often produced by Coxsackie A16. In most cases infection is asymptomatic or causes only mild symptoms. In others, infection produces short-lived (7-10 days) fever and painful blisters in the mouth (a condition known as herpangina), on the palms and fingers of the hand, or on the soles of the feet. There can also be blisters in the throat, or on or above the tonsils. Adults can also be affected. The rash, which can appear several days after high temperature and painful sore throat, can be itchy and painful, especially on the hands/fingers and bottom of feet.
Other diseases include acute haemorrhagic conjunctivitis (A24 specifically), herpangina, and aseptic meningitis (both Coxsackie A and B viruses). Coxsackie B viruses also cause infectious myocarditis, infectious pericarditis, and pleurodynia.
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the antiplatelets drugs are classified into 3 groups according to their mode of action
-anti COX====>aspirin
-anti ADP====>ticlopidine and clopidogril
-anti glucoprotien iib/iiia receptors===>abciximab and tirofiban + eptifibatide
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hello tec .....nice to see here in the forum...thx for the notes
can u tell me abit about anti HIV drugs?
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PTU is safer in pregnancy
I can be used preoperativly to decrease the size of the thyroid gland
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hello zakha how are u?
what do u want to know abt hiv drugs? do u want me to post its mechanism of action?
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reverse transcriptase inhibitor
Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase enzyme that HIV needs to reproduce.
Mechanism
When HIV infects a cell, reverse transcriptase copies the viral single stranded RNA genome into a double-stranded viral DNA. The viral DNA is then integrated into the host chromosomal DNA which then allows host cellular processes, such as transcription and translation to reproduce the virus. RTIs block reverse transcriptase's enzymatic function and prevent completion of synthesis of the double-stranded viral DNA thus preventing HIV from multiplying.
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