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benign prostatic hypertrophy - proteus
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01-22-2008, 02:22 PM
A 72-year-old male with a long history of benign prostatic hypertrophy is started in on an alpha-1 blocking medication that is specific for the alpha-1A receptor subtype. The medication most likely started is which of the following?
A. Alfuzosin B. Prazosin C. Indoramin D. Tamsulosin E. Terazosin
01-24-2008, 02:15 PM
Choice (D) is the correct answer. Tamsulosin is an alpha-1 receptor blocker that is specific for the alpha-1A receptor subtype found in the prostate. Alpha-1 blockade results in decreased smooth muscle tone in the bladder neck, prostate, and urethra. This acts to increase urine flow and relieve the symptoms of benign prostatic hypertrophy (BPH). BPH symptoms include increased urinary frequency, urgency, and hesitancy. Patients may feel like they never completely empty their bladder. Dribbling is common. Alfuzosin (Choice A), prazosin (Choice B), and Indoramin (Choice C) are selective short-acting alpha-1 receptor antagonists. Terazosin (Choice E) is also a selective alpha-1 receptor antagonist but is longer acting.
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