07-30-2008, 09:15 PM
EM pic ans?
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to unstable angina - dewdrops822001
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07-30-2008, 09:15 PM
yes nicholsky sign is important but the biopsy is more important
07-30-2008, 09:16 PM
guys gotcha go see somebody in 10 mins.. so i guess i ll leave now.. pls carry on with the discussion!! it was nice to hv this discussion..
07-30-2008, 09:18 PM
Pemphigus vulgaris
Immunologic disease with IgG antibodies directed against the intercellular attachment sites (desmosomes) between keratinocytes (type II cytotoxic antibody hypersensitivity reaction); produces vesicles (blisters < 5 mm) and bullae on skin and within oral mucosa; vesicles are intraepidermal and have a suprabasal location (just above the basal cell layer), leaving basal cells intact and looking like a row of tombstones; due to detachment of individual keratinocytes from each other (acantholysis), keratinocytes are present within vesicle fluid; bullae exhibit Nikolsky's sign (outer epidermis separates easily from the basal layer with minimal manual pressure) Bullous pemphigoid Immunologic vesicular disease (IgG antiepithelial antibodies directed against the basement membrane; type II hypersensitivity) in which vesicles are in a subepidermal location; Nikolsky's sign is negative; acantholysis is not present
07-30-2008, 09:20 PM
wat s ur source?? did u copy paste it or write the last message??
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