idiotope vs paratope and Epitope vs Hapten - match099

[ArchivalUser]

thank u guys my concept clear too

[ArchivalUser]

IDIOTYPE is the portion of variable region of immunoglobulins or T-cell receptors, that determines which type of antigen will bind to them ( on broader terms )
note- multiple idiotOPES join to form a particular idiotype.

PARATOPE is a region within the idiotype (usually the extreme end of variable region- N-terminus) thats binds epitope (i.e. the site where actual bonds are made between antigen and the antibody)

EPITOPE is a specific region on the antigen that fits into the paratope of the idiotype.

[ArchivalUser]

@technodoctor thanks

If both "IdioTOPES" and the "Paratopes" bind to Antigen(Epitope) , then what's the difference b/w these two ??????

or are u saying that the "IdioTOPES" do not bind to the Antigen (Epitope) ??

[ArchivalUser]

Haptens are very small and they cannot stimulate immune response unless they attache to bigger molecules, but Epitopes are bigger and they have the ability of immune response stimulation individually.