12-17-2008, 03:57 AM
A 25 year old man of Eastern European Jewish descent is being evaluated for a right hip fracture and splenectomy. He reports recurrent acute episodes of bone pains for the past 5 years. complete blood count shows ESR of 2000,000/mm3 leukocyte count 3,300/mm3 platelet count of 70,000/mm3.X ray demonstrates multiple osteolytic lesions in the vertebral column and femurs. A bone marrow aspirate reveals clutures of histiocytes showing fibrillary cytoplasms with a finely and uniformly vaculated appearance. The fibrillary material in the cytoplasm is PAS positive.What is the most effective treatment available for this condition?
a. Administration of pyridoxine and folate
b. administration of hematin
c. allogenic bone marrow transplantation
d. cytotoxic drugs such as hydroxyurea
e. high carbohydrate diet
f. replacement therapy with alglucerase
g. splenectomy
a. Administration of pyridoxine and folate
b. administration of hematin
c. allogenic bone marrow transplantation
d. cytotoxic drugs such as hydroxyurea
e. high carbohydrate diet
f. replacement therapy with alglucerase
g. splenectomy
