Psychopharmacology - karim12345

[ArchivalUser]

Which of the following drugs is the least sedating and anticholinergic, which can be prescribed safely to elderly patients with depression?

a.fluoxetine
b.MAOI
c.Imipramine
d.Sertraline
e.Trazodone

[ArchivalUser]

cc

[ArchivalUser]

no ...
ALL TCAs have anti-cholinergic and sedating SE...

[ArchivalUser]

dd

[ArchivalUser]

ddddddd

[ArchivalUser]

ddd

[ArchivalUser]

correct ans: DDDDDD

+Trazodone: very sedating but no anti-cholinergic SE.
+Imipramine (TCA): sedating and anti-cholinergic SE.
the least sedating and anticholinergic among TCA drugs are: Desipramine; Nortriptyline (Best TCAs for elderly pts).
+MAOI: sedating(very common)++ but no anti-cholinergic SE.
+SSRI: *Fluoxetine(PROZAC) ==>impaired metab. in elderly pts
*Sertraline, citalopram and Escitalopram ==>least likely to interfere w hepatic drud metabolism.
*Sertraline(ZOLOFT)==>the lowest incidence of sedation , anti-cholinergic SE and orthostatic hypotension among all SSRI.