04-26-2009, 07:35 PM
causes hyper uricemia and predisposes to gout ... can anyone plz explain the mechanism??
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thiazide diuretics - torsades
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04-27-2009, 05:23 AM
-main mech by which thiazides cause hyperuricemia is due to hypovolemia.
-urate handling occurs in PCT. -hypovolemia induces excess Na resorption in PCT-----> Na/H exchanger throws out H+ -----> increased OH- ions in cell tend to follow H+ outward, and Urate is absorbed in place of OH-. low-dose thiazides or maintaining normovolemia minimizes this effect. |
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