02-01-2012, 02:14 PM
O2-dissociation curve in a pt with "Septic Shock".
A-Right shift
B-Left shift
C-No change
and why?
A-Right shift
B-Left shift
C-No change
and why?
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q.5_____________? - sarim
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02-01-2012, 02:22 PM
BB....left shift because of hypophosphatemia/low 2,3 DPG......
02-01-2012, 02:46 PM
Right
 In "Septic Shock"------ there are "LOW levels of 2,3 BPG" ----> Lt shift of curve. as well as in "HYPOphosphatemia"
02-01-2012, 02:54 PM
Thank you, Sarim.
I read somewhere that there is often hypophosphatemia in septic shock, regardless of whether the patient received hyperalimentation or not.
02-01-2012, 03:09 PM
could you please explain about the mechanism of hypophosphatemia and low level of 2,3 BPG in septic shock patients. Thank you
02-01-2012, 03:41 PM
CO would also cause left shift..
The mechanism by which hypophosphatemia develops involves redistribution of phosphate from extracellular fluid into the cells. Acute respiratory alkalosis as occurs in sepsis causes a rise in intra-cellular pH, which stimulates phosphofructokinase activity and glycolysis [15]. The stimulated glycolysis increases the formation of phosphorylated carbohydrate compounds, which draw their phosphate from the extracellular fluid, causing decreased serum Pi levels |
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