NBME Question....Form 11 block 2 ! - kindmd

[ArchivalUser]

25yr old dude w/ type I diabetes comes to you cuz of poor diabetic control for 3 months. He has ketones in his urine, and his blood glucose conc. has been in 200-400 mg/dl range, particularly after exercise. he has been receiving 2 injections of insulin daily. Physical exam shows no abnormalities. His HA1C is 12%. After exercising on treadmill for 45 minutes, that patient has a increase in serum glucose from 175 to 225 mg/dl. Which of the following hepatic enzymes is most likely elevated initially by exercise in this patient?

A. Debranching ezyme
B. Phopholicpase C
C. Phosphorylase kinase
D. Portein Kinase B


****I JUST WANT AN EXPLANATION FOR A plz....In 1st aid, it mentions that debranching enzyme is used in converting to glucose*****

[ArchivalUser]

Explain A plz....!

[ArchivalUser]

debranching enzyme is used to degrade glycogen to glucose .......

[ArchivalUser]

yeah so wouldn't that be also used when you want glucose during exercise ?

[ArchivalUser]

yes ,,its

[ArchivalUser]

ccc

[ArchivalUser]

debranching enzyme only breaks the 1,6 glucosidic bonds (at the branch points), whereas muscle phosphorylase is the rate limiting enzyme of glycogenolysis that releases G-1-P by breaking a 1.4 glycosidic linkages.

[ArchivalUser]

Still confused guys.....

Ok, if u say which is activated 1st, then ok, i would say choice C.....But A would be activated as well, it's just it would be a bit "later down the road"....is tht wht the question is going behind ?

[ArchivalUser]

some one....clear my confusion !!!

[ArchivalUser]

debranching enzyme is the only enzyme that release free glucose directly by cleaving 1,6 glucosidic bond at branch point

but is it affected by exercise ?????/
i dont know