02-29-2012, 03:09 AM
what its function?how it affect translation?
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Kozak sequence - aprna
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02-29-2012, 04:55 AM
initiation of translation
messenger RNA binding to ribosome at 3bp infront of AUG condon code either adenine or guanine
02-29-2012, 06:55 AM
where it is given, i didn't find it in kaplan or fa.
02-29-2012, 07:02 AM
"Ribosomal binding site" is simply the address to go to for ribosome to begin translation process. Ribosome must find the 5 prime end of mRNA before it can begin translation process ."Ribisomal Binding site" is the 5 prime cap of mRNA that the ribosome find and than binds to in order to get ready for the translation process. It is the untranslated part(UTR) of mRNA and helps in directing the process.
After finding the ribosome binding site in eukaryotes, the ribosome specifically binds to the" Kozak consensus sequence /Kozak SEQUENCE".kOZAK SEQUENCE is like a building at a particular address that some one needs to go to. Now Kozak sequence conatins the start codon AUG. A tRNA with complementary anti codon than binds to this "start codon" that lies within the Kozak Sequence . And than bigger subunit of ribosome attaches to this complex and translation process actively starts. So when Ribosome binding site is the physical address of a place, kozak sequence is the building,and start codon is the room where things starts happening. |
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