Question........... - psychmledr

[ArchivalUser]

Biopsy of an ulcerated gastric lesion in a 60-year-old smoker shows glands containing cells with enlarged hyperchromatic nuclei below the muscularis mucosa.
Which of the following is most strongly associated with oncogenesis caused by the most likely infectious organism in this case?

A. CagA gene
B. E6
C. t (8;14)
D. t (11;18)
E. VacA gene

[ArchivalUser]

ee

[ArchivalUser]

Helicobacter pylori

cagA and vacA Gene

[ArchivalUser]

i think so, a & e

[ArchivalUser]

the most important is cagA

[ArchivalUser]

Correct answer is A....cagA

CagA: cytotoxin-associated gene A is more associated with gastric carcinoma

vacA: vacuolating cytotoxin gene A is more associated with peptic ulceration

They may both be present with or without disease.

[ArchivalUser]

Thank you for the nice Q

[ArchivalUser]

You are welcome

[ArchivalUser]