Molecular Biology**1 - maryam2009

[ArchivalUser]

Tumor-suppressor genes includes p53 and Rb. How would a "gain-of-function" mutation likely affect the cell?

A) The cell would divide constantly because of the loss of cell cycle repression.


B) The cell would divide much less frequently because of the extra cell cycle repression.


C) The cell would divide normally because these genes have no effect on cell cycle control.


D) The cell would commit suicide by apoptosis.

[ArchivalUser]

aaaa

[ArchivalUser]

BB

[ArchivalUser]

b

[ArchivalUser]

Answer b is correct, because tumor suppressor genes normally function to repress the cell cycle, so a gain of function would increase this normal activity causing excess cell cycle repression.

[ArchivalUser]

gain of fuction mutation in tumor supressor gene p53 cause enhancement of tumorigenicity and therapy resistance. correct A

[ArchivalUser]

Tumor suppressor gene or anti-oncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a **loss or reduction in its function***, the cell can progress to cancer, the stem cell talked about ***a "gain-of-function" mutation *** not loss of the function.