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NBME F1B2Q4 -67yo man with lethargy & hyponatremia - maritzasf
#1
4. A previously healthy 67-year-old man is admitted to the hospital because of lethargy, confusion, muscle cramps, and decreased appetite for 7 days. He appears ill. His temperature is 37 C (98.6 F), blood pressure is 120/70 mm Hg, pulse is 98/min, and respirations are 20/min. Breath sounds are diminished at the right lung base. Neurologic examination shows no abnormalities except for lethargy. Serum studies show:

Na+ 114 mEq/L
K+ 4.3 mEq/L
Creatinine 1 mg/dL
Thyroid-stimulating hormone 4.1 μU/mL

An x-ray film of the chest shows a 2-cm nodule in the right lower lobe and mediastinal adenopathy. A biopsy specimen of the nodule is most likely to show which of the following?

A) Adenocarcinoma
B) Clear cell carcinoma
C) Mesothelioma
D) Small cell carcinoma
E) Squamous cell carcinoma
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#2
d.
learn it this way all syn are associated with small cell except hypercalcemia which is related to squamous cell of course not 100 percent but i memorized this waySmile)
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#3
answer:
D) Small cell carcinoma

--------------------------------

Small Cell Carcinoma (Oat cell)

LOCATION:
Central

CHARACTERISTICS:
Undifferentiated > Very aggressive
Ectopic production of ACTH or ADH
 Lead to Lambert-Eaton: Ca 2+ autoantibodies
 SIADH (normovolemic Hyponatremic Small dark blue cells

*** For Squamous cell carcinoma, there is a mnemonic:
SCa++mous CC > Hypercalcemia
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#4
SIDH,USUALLY ASS with small cell,but small cell is also central,so am confused bet A)&D).
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#5
now that you mention, i think i saw a qs like this on UW? I think it was adeno? Oh boy! now I have 2dle thoughts :?
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#6
D is the answer
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