Question..............3 - psychmledr

[ArchivalUser]

Histologic sections from an irregular, enlarging brown lesion on the left forearm of a 23-year-old male who is HIV-positive would most likely reveal which of the following?

A. Irregular vascular spaces lined by nests of uniform cells
B. Multiple dilated endothelial-lined vessels that lack red blood cells
C. Numerous neutrophils, nuclear dust, and purple granules
D. Proliferating blood vessels, endothelial cells, and fibroblasts
E. Proliferating spindle stromal cells with slitlike spaces and extravasation of erythrocytes

[ArchivalUser]

EE

[ArchivalUser]

kaposis sarcoma

eee

[ArchivalUser]

"E" is correct.

Kaposi’s sarcoma (KS) comprises four distinct forms.
The classic, or European, form has been known since 1862. It occurs in older men of Eastern European or Mediterranean origin (predominantly Italian or Jewish) and is characterized by purple maculopapular skin lesions of the lower extremities and visceral involvement in only 10% of cases.

The African form occurs in younger people and is more aggressive; it often involves lymph nodes in children.

The rare form in immunosuppressed recipients of renal transplants often regresses when immunosuppression stops.

In the epidemic form associated with AIDS, skin lesions may occur anywhere and disseminate to the mucous membranes, GI tract, lymph nodes, and viscera.

Histologic determination is difficult, but all four clinical types appear similar. In the early stages, irregular, dilated epidermal vascular spaces, extravasated red cells, and hemosiderin are characteristic. This histologic appearance is very similar to that of granulation tissue or stasis dermatitis. Later in the disease process, more characteristic lesions show spindle cells around slit spaces with extravasation of erythrocytes.

In contrast, irregular vascular spaces lined by nests of uniform cells describes the histologic appearance of a glomus tumor.

Multiple dilated endothelial-lined vessels that lack red blood cells describes the histologic appearance of lymphangiomas.

Numerous neutrophils, nuclear dust, and purple granules characterize bacillary angiomatosis.

Proliferating blood vessels, endothelial cells, and fibroblasts suggest granulation tissue.

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