Bug of the day - bugguy19

[ArchivalUser]

Mycobacterium leprae

Acid fast bacillus
Obligate aerobe
Facultative intracellular
Non motile
Catalase +ve

Phenolase +ve (used for diagnosis)
Grow at low temperatures
Can not be cluttered in vitro (only in vivo only armadillos or mouse foot )

Leprosy ✈✈✈✈✈spectrum of ds

1/lepromatous leprosy
Weak immune response
Organism found everywhere
Multiple skin lumps and pumps, leonine face, peripheral neuropathy


2/intermediate form

BL , BB , BT

3/Tuberculoid leprosy
Intact cell mediated immunity with intense response
Granuloma formation limit spread
Localized damage ✈✈✈✈✈Thickened nerves and hypopigmented skin, peripheral neuropathy

Dx✈✈✈

skin/ nerve biopsy (granuloma in tuberculoid, acid fast bacteria in lepromatous)
Lepromin skin test to determine prognosis(+ve in tubercuoloid )


Treatment ✈✈✈✈

Used in combination to prevent resistance (Dapsone, Rifampin,clofazimine)

[ArchivalUser]

leprosy medication cause reaction to the dead bacteria Do NOT stop treatment

Type 1 reaction✈✈✈✈✈
Intensified tuberculoid reaction
ttt by prednisone


Type2 reaction ✈✈✈✈✈
Immune complex deposition (erythema nodosum leprosum )
ttt by thalidomide (only approved in US )

[ArchivalUser]

Thanks

[ArchivalUser]

OK forum members let me grab my Energy drink then we will do Coxiella bumetii (Q fever)

[ArchivalUser]

HI Bugguy19,
I am sorry, I missed the bugs for couple of days due to some problems.I got a nice review now which I had missed.thank you for posting buggies so well.
Back with the buggies.Ready to check with coxiella burnetii(you got spelling wrong ;-)

[ArchivalUser]

hi rukhz , welcome back, thank you for the correction

[ArchivalUser]

coxiella burnetii

Poorly stainable Bacteria
Obligate intracellular (can't make ATP by her self )

Zoonotic ✈✈✈ cattle, sheep, goats
No arthropod vector needed
Direct airborne transmission of the endospore or ingestion of in pasteurized milk

Q fever✈✈✈✈ headache, viral like pneumonia No rash
Complications ✈✈✈Hepatitis , Endocarditis

Dx ✈✈✈✈ serology
ttt✈✈✈✈✈✈Doxycyclin, Erythromycin
Prevention ✈✈✈✈ pasteurization of milk

[ArchivalUser]

You missed nothing..nice

[ArchivalUser]

hi friends , bugs make me little bit sick so this weekend we gonna have some diffefernt topics then from Monday to Friday we gonna finish our last bacterial group (poorly stainable )

so

Saturday we will do bactrial genetices in v. simple way

Sunday we will do mechanisms of bacterial drug resistance (only HY)

[ArchivalUser]

for general simple idea o f bacterial genetics watch this 9 min video https://www.youtube.com/watch?v=7sZ5Nz8_cfc