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An otherwise healthy, 37-year-old leather tanner presents with a 2-day history of a lesion on his left hand.It started as a 2 cm papule developing into a painless ulcerous vesicle with a black necrotic eschar, He complains of left axilla tenderness as well. What is the likely diagnosis?
a Lymphocutaneous tularemia
b Bubonic plague
c Staphylococcal abscess
d Cutaneous anthrax
e Ascending lymphangitis
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A 54-year-old man with a history of type 2 diabetes comes to the physician because of an unresolved skin lesion on his foot. The lesion appeared several weeks ago, but recently has expanded and become painful. Physical examination shows a 5-cm lesion withablack,necroticcenterandraisederythematousedges. Whichofthefollowingtoxinshasamechanismofactionmost similar to the toxin most likely responsible for this patient's skin lesion
a. Anthrax toxin
b . Botulinum toxin
c Choleratoxin
d .Ctostridiumpertringens alpha toxin 0 E.Diphtheriatoxin
F. Escllericllia coli labile toxin
G. Pertussis toxin
h .Shigatoxin
I. Streptococcal erythrogenic toxins O J.Tetanustoxin
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The lesion looks more like pseudomonas infection which inactivate EF2 and only Corynbacterium diptherias can mimic the mechanism and is not one of the options.
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A will be best answer cos the toxin is an Edema factor that mimic the adenylate cyclise enzyme by increasing cAMP
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@adexson the answer is diphtheria toxin you are right
any reason ?