q..... - ahmad12801

[ArchivalUser]

Chromatin remodeling is associated with alterations in the transcriptional activity of genes in

the region of the remodeling. Which of the following statements is most correct concerning

the events of chromatin remodeling


A) Chromatin remodeling occurs predominantly in regions enriched in CpG dinucleotides

B) Histone acetylation tends to destabilize chromatin structure

C) Methylation of cytosine residues induces the remodeling event

D) Methylation of histone H1 is sufficient to stimulate remodeling

E) Remodeling is necessary to induce the property of genomic imprinting

[ArchivalUser]

bb

a d e-excluded

[ArchivalUser]

bb

[ArchivalUser]

With methylation you are always deactivation a gene! It rules out C and D.
Choice A deals with the upstream promoter elements which also includes CCAAT box.
Choice E I have no idea what it is talking about!
Choice B is clearly the answer. Acetylation of histone proteins helps in opposing the negative charges and then loosens the chromatin!

[ArchivalUser]

Gene expression(by remodelling) not occurred in imprinted genome
and methylation is responsible for genomic imprinting.So E excluded

[ArchivalUser]

B

epigenetics