08-25-2015, 09:03 AM
43. A 20-year-old man is brought to the physician because of a 4-hour history of abdominal pain, nausea, and vomiting. He says that he had been drinking ethanol heavily
all weekend, and he took three doses of acetaminophen within 2 hours after the onset of a severe headache Monday morning. This patient is at increased risk for liver
injury because of which of the following actions of ethanol?
A) Activation of IgE-mediated mast cell degranulation
B) Decreased acetaminophen clearance via glucuronidation
C) Increased bioavailability of acetaminophen
D) Induction of cytochrome P450 enzymes that activate acetaminophen to a hepatotoxic metabolite
E) Metabolic acidosis due to an increased NADH:NAD+ ratio
The answer is not B
please explain the answer
all weekend, and he took three doses of acetaminophen within 2 hours after the onset of a severe headache Monday morning. This patient is at increased risk for liver
injury because of which of the following actions of ethanol?
A) Activation of IgE-mediated mast cell degranulation
B) Decreased acetaminophen clearance via glucuronidation
C) Increased bioavailability of acetaminophen
D) Induction of cytochrome P450 enzymes that activate acetaminophen to a hepatotoxic metabolite
E) Metabolic acidosis due to an increased NADH:NAD+ ratio
The answer is not B
please explain the answer