Question.... - soniashaik

[ArchivalUser]

RBCs from a 25 y/o African American male who suffers from periodic hemolysis demonstrate a low activity of Glucose-6-phosphate dehydrogenase. Deficiency of which of the following erythrocyte enzyme has the same pathophysiology as this pt’s condition ?

A-Pyruvate kinase
B-Hexokinase
C-Transketolase
D-Bisphosphoglycerate mutase
E-Glutathione reductase

[ArchivalUser]

E. Because both enzymes play an important role in antioxidation mechanism which eliminate free radicals.
G6pd is responsible for generate NADPH which is enzyme cofactor for Glutathione reductase.

[ArchivalUser]

E is the answer